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Options like Colace or MiraLAX can help, but stimulant laxatives should be avoided unless advised by your Care Team
The mechanisms and regulation of autophagy and mitophagy have attracted considerable attention due to their impact in health and disease and have been recently reviewed ( Atg5 , an essential gene that regulates autophagy, has been shown to protect against APAP-induced liver injury due to compensatory mechanisms ( Atg5 suppresses autophagy and p62 degradation, which results in the persistent activation of nuclear factor (erythroid-derived 2)-like 2 (NFE2L2) by releasing the inhibition of KEAP1 on NFE2L2
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