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This pulsatile pattern preserves the negative feedback loop: when GH and IGF-1 reach adequate levels, somatostatin signals the pituitary to pause secretion (Ishida et al., JCSM Rapid Commun, 2020)

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I think youll see [more approvals] as other medications come online. Still, the demand for these medications is so high that pharmaceutical companies have had difficulties producing enough of them