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Many underlying issues remain untouched, including: Hormonal imbalances Insulin resistance Chronic inflammation Poor gut health Stress-related cortisol elevation Nutrient deficiencies When the medication is stopped, the body often rebounds because the root causes were never resolved

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In neuroblastoma SH-SY5Y cells exposed to hyperglycemia, a condition known to increase GSK3 activity [119], melatonin exerted an inhibitory effect on the GSK3 signaling pathway, likely through the activation of its melatonin receptor [62]

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