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Once senescent cells are removed, the downstream benefits continue to develop as: SASP-driven inflammation progressively resolves Stem cell niches, previously suppressed by SASP factors, may reactivate Tissue remodeling and repair processes engage in cleared areas The paracrine senescence cascade (where SASP converts healthy cells to senescent ones) is interrupted In mouse models, improvements in kidney function and physical fitness persisted and in some cases continued to develop during the weeks following treatment cessation (Baar et al., 2017)
The full 12-week schedule requires 5660 injections, depending on whether the maintenance phase is dosed 2-3x per week
Appointments are designed to be straightforward, supportive, and unhurried
Until then, every comparison, including this one, relies on imperfect cross-trial analysis