Together, the data using mouse models of MASH reveal an EC-specific, weight-loss-independent, semaglutide-regulated, GLP-1R-dependent intrahepatic network for improving liver health, the scientists said
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Led by Duke scientist Jonathan Campbell, PhD , the team of obesity and diabetes researchers analyzed pancreatic tissue from mice, as well as from humans of varying ages, body weights, and diabetes statuses
By contrast, those on external testosterone (Group C) saw testosterone levels go up (as expected) but their LH/FSH were suppressed, and those on gonadotropins (Group A) saw some improvement in T but not as robust as liraglutides effect
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