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Furthermore, acute exposure of Caco-2 cells to alcohol was associated with reduced Ras-related protein 2 (Rap2) activity, and enhanced myosin light chain kinase (MLCK) activity, changes consistent with impaired JAM-A signalling
Reduced capillary density, altered microcirculation and decreased muscle blood flows could help explain that finding
It identified no adequate acute, repeat-dose, genotoxicity, reproductive-toxicity or carcinogenicity programme
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