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The moderate half-life enables multiple daily administration while maintaining pulsatile rather than sustained GH elevation

2022 Apr 1;28(2):500-535

Food and Drug Administration (FDA) in 2011

The dose of vitamin B12 injection for adults may vary depending on the problem to be treated: Treatment of mild nerve pain : the initial dose is 5,000 IU until pain resolves Treatment of intense nerve pain: the initial dose can be increased to 15,000 IU per day and reduced by the doctor as pain resolves Treatment of pernicious anemia: the dose can vary from 100 to 1000 IU per day and the treatment time varies from person to person

It is often thought that in an enzyme protein, functionally critical AA residues are less likely to change over evolutionary times