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293 PK deficiency may be also caused by mutations not directly involving the PKLR gene as demonstrated by a deficiency of PK being one of the key features of severe congenital hemolytic anemia caused by mutations in the key erythroid transcription factor KLF1
The exact dose depends on each patients response, lifestyle habits, and overall health
Correcting a significant deficiency often starts with weekly or biweekly injections until levels come up
How can these risks be managed effectively
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