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Semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) contain synthetic, longer-acting versions of the hormone designed to amplify those effects
There are several reasons behind this recommendation
10.4103/ijp.IJP_115_18 74 TriveniA
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Results showed dose-dependent weight loss: the 0.25mg dose produced 4.5% additional weight loss beyond diet and placebo, the 0.5mg dose achieved 9.2% weight loss, and the 1.0mg dose resulted in 10.6% weight lossrepresenting approximately twice the efficacy of other approved obesity drugs available at that time
