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Dynamic imaging of LDH inhibition in tumors reveals rapid in vivo metabolic rewiring and vulnerability to combination therapy

Your body needs a certain amount of calories just to exist

Accordingly, mitochondrial fusion preserves the mitochondria for greater energy production during conditions of high metabolic activity, whereas fission facilitates the removal of damaged mitochondria via mitophagy (Scheibye-Knudsen et al., 2015)

Consistent Medication Supply Established clinics and medical providers typically have more reliable access to FDA-approved medications

This discrepancy may be attributed to several alternative, non-mutually exclusive hypotheses that must be considered with equal weight: (1) a misalignment between the drugs therapeutic window and the disease stage of the enrolled patients (the prevention hypothesis)