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Certain situations make early dosing inadvisable

[4] [6] Medication review: A thorough review of concomitant medicines that may independently raise heart rate is advisable, including sympathomimetics, SNRIs, tricyclic antidepressants, and beta-2 agonists Lifestyle measures: Reducing caffeine intake, managing stress, and ensuring adequate sleep can all contribute to heart rate regulation Cardiac monitoring: In patients with pre-existing cardiac conditions, an electrocardiogram (ECG) or ambulatory heart rate monitoring may be warranted Specialist referral: If tachycardia persists or is associated with arrhythmia, referral to a cardiologist should be considered In some cases, if the heart rate elevation is persistent and symptomatic despite dose adjustment, discontinuation of retatrutide may be necessary

These interactions may increase the risk of kidney damage or alter the drugs effectiveness

Read More Eli Lilly and Company plans to ramp up production of the active ingredient for a once-daily weight-loss pill, even though the drug candidate has yet to receive approval from the US Food and Drug Administration

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