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Continuous MT-1 administration beyond 3 weeks causes melanocortin receptor desensitization, where melanocytes downregulate MC1R surface expression in response to sustained agonist binding
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Hence, hematopoietic and EC Tie2 + lineages do not contribute significantly to kidney Glp1r expression
If discomfort symptoms such as pain, redness, and itching occur, the injection should be stopped immediately and corresponding treatment measures should be taken
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