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Luthi et al., however, did not examine treatment duration as a factor, limiting direct comparisons [23]
Even more encouraging, tirzepatide was associated with reduced urine albumin-to-creatinine ratio (UACR) after 24 weeks, sustained through week 72, without detrimental changes to estimated glomerular filtration rate (eGFR)
Based on available literature, the oral mass dose to match parenteral efficacy at systemic endpoints appears to be 5-10 higher
Wegovy is not on any standard provincial formulary for weight management
Important safety considerations include a boxed warning for medullary thyroid carcinoma risk, monitoring for pancreatitis (severe abdominal pain), gallbladder disease, and potential hypoglycemia when used with insulin or sulfonylureas
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