Greater weight loss potential The SURMOUNT-5 trial, published in NEJM in 2025, directly compared tirzepatide against semaglutide in adults with obesity (without diabetes)
Why this matters for shippers For shippers across Food & beverage and pharmaceuticals, the rise of GLP-1 drugs is more than a healthcare trend
Current studies suggest that peripherally administered GLP-1RA has low concentrations in the cerebrospinal fluid, and higher doses or improved delivery systems (e.g., nanoparticles, liposome encapsulation) may be needed to increase brain exposure
While this trial did not focus on stopping treatment, it helps show why patients may experience major changes in appetite, weight, and metabolism while taking medications like Mounjaro or Zepbound
Salmon works too, but some people find it too rich on semaglutide