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Since APE1/Ref-1 expression represents a molecular marker of oxidative stress, it would be important to understand the dissection of signaling pathways responsible for its role in regulating the mechanisms of ROS-induced cell responses
NAC appears to be a good candidate because of its role in restoring GSH levels, antioxidant properties, and its ability to break disulfide bonds 48
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Role for glutathione peroxidase-4 in brain development and neuronal apoptosis: specific induction of enzyme expression in reactive astrocytes following brain injury
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