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Impairment Of fertility Studies in which male and female rats received twice daily subcutaneous doses lixisenatide of 2, 29, or 414 mcg/kg prior to pairing through gestation day 6 did not indicate any adverse effects on male or female fertility in rats up to the highest dose tested, 414 mcg/kg, or approximately 400times the clinical systemic exposure at 20 mcg/day based on mcg/m

9 A synthetic version of exendin-4, called exenatide (brand name Byetta), became the first GLP-1 receptor agonist approved by the FDA on April 28, 2005

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