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Why Some People Experience Insomnia with Tirzepatide More Than Others Genetic variation in GLP-1 receptor sensitivity and peptide metabolism can explain why two patients on the same tirzepatide dose experience vastly different sleep outcomes
This cytoprotective effect is mediated by PI3K and partially dependent on ERK1/2 and seems to be glucose-independent
Discussing potential adjustments to medication dosage or timing may alleviate symptoms and improve energy levels
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