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Upregulated gene sets included those associated with GPCR signaling, neuropeptide receptor interactions and ligand binding, cilia formation, metabolic processes, and endocrine function Supplemental Figure 5B)

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Procedures including Roux-en-Y gastric bypass, sleeve gastrectomy, and adjustable gastric banding produce 20-35% total body weight loss and significant improvement in obesity-related comorbidities including type 2 diabetes, hypertension, and obstructive sleep apnea

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