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The p53 protein, a key human tumor suppressor, regulates the expression of oncogenes and downstream signaling pathways, contributing to biological effects (7275): Beyond its role in cancer, p53 is highly expressed in the brain, where it influences dendritic growth, oxidative stress response, apoptosis and autophagy, making p53 dysfunction and associated pathways noteworthy in the pathogenesis of AD (7678)

Nuclear factor erythroid-derived 2-like 2 (NFE2L2, Nrf2) mediates exercise-induced mitochondrial biogenesis and the anti-oxidant response in mice

GPX2 suppression of H2O2 stress regulates cervical cancer metastasis and apoptosis via activation of the -catenin-WNT pathway

2020;72:e108 Jumper J, Evans R, Pritzel A, Green T, Figurnov M, Ronneberger O, et al