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DiNicolantonio JJ, Niazi AK, McCarty MF, Lavie CJ, Liberopoulos E, OKeefe JH
Significant evidence from large, randomised trials has shown that SGLT2Is have a positive impact on heart failure with reduced ejection fraction (HFrEF) as well as on HFpEF
The EMPOWER study evaluated the effects of intermittent, bilateral blockade of bilateral subdiaphragmatic vagal nerves to stop both ascending and descending neural traffic, speculating its involvement in satiety, reduced food intake and weight loss in morbid obese individuals (Figure 1)
Limit caffeine and alcohol, which have diuretic properties and may exacerbate urinary frequency
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