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While effective at achieving and maintaining weight loss, long-term use of incretin mimetics is likely needed to maintain weight since weight regain is common following drug discontinuation, with a return to baseline within a year 12,13

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HF diabetic mice showed a significant lower respiratory exchange ratio (RER) compared to normal-diet (ND)-fed mice, indicating an increased fat oxidation in HF diabetic controls, while CB0313.1 can partially reverse the decrease (Fig

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It is not known if Trulicity will cause thyroid tumors, or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people