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"Just as recent genetic research is helping explain why about 10% of GLP-1 users don't lose weight, there are likely genetic and epigenetic factors that contribute to wide variation in how these treatments affect people psychologically." Even so, Abdullah says he keeps a closer eye on patients with certain risk factors, including: A history of major depressive disorder, anxiety, ADHD or an eating disorder A history of binge eating or using food to cope with stress or emotions A history of responding strongly to antidepressants or stimulant medications Rapid weight loss or inadequate caloric intake Major life stressors or significant life transitions happening at the same time What to do if you notice mood changes on Ozempic or another GLP-1 If you're feeling off on Ozempic or another GLP-1 drug, don't stop the medication abruptly on your own
Wake DJ, Gibb FW, Kar P, et al
Always consult your healthcare provider before making major changes to your dosing schedule or traveling with a large supply of medication
Semaglutide (Wegovy) works by mimicking the hormone GLP-1, which slows digestion and helps your brain regulate appetite by reducing hunger sensations
This staggering impact has heightened the focus on preventive healthcare as a vital strategy to reduce the burden of these conditions
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