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The tumor-bearing mice were intravenously administered Cy7.5-labeled NP4 at a dosage of 2 mg/kg (Ru) once the tumor volume reached approximately 200 mm
The absence of weight loss despite induction of CTA in lean mice further indicates that enhanced nausea is unlikely to account for its body weight-reducing effects in DIO mice
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138,139,140 These transport mechanisms, often coupled with vesicular trafficking and metabolic reprogramming, significantly reduce intracellular drug accumulation, attenuate target engagement and contribute to immune evasion, collectively undermining therapeutic efficacy
For weight management medications, NICE guidance specifies different stopping rulesfor example, Wegovy treatment should be reviewed after 6 months, and Saxenda should be discontinued if less than 5% weight loss is achieved after 12 weeks at the maintenance dose
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