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Abstract Recent large clinical trials on sodium-glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists, with the aim of verifying cardiovascular safety, have revealed that these medications have a preventative advantage on adverse cardiovascular outcomes, including worsening of heart failure and deterioration of nephropathy, in patients with type 2 diabetes (T2D)
This can cause these well known gastrointestinal side effects
Patients with a personal or strong family history of cancer should discuss this carefully with their provider before starting
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But Rybelsus went through extensive clinical trials to prove its efficacy and required a specialized absorption enhancer (SNAC) to achieve adequate bioavailability
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