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Procedures such as sleeve gastrectomy or gastric bypass should only be considered in specialist centres with expertise in both bariatric surgery and IBD management
| Vial Size | BAC Water for 5mg/mL | BAC Water for 2.5mg/mL | |-----------|----------------------|------------------------| | 5mg | 1.0mL | 2.0mL | | 10mg | 2.0mL | 4.0mL | | 20mg | 4.0mL | 8.0mL | At 5mg/mL, every 10 units on an insulin syringe equals 0.5mg of semaglutide
In rats fed with high-fat diet, the density of intestinal epithelial cells producing GLP-1, secretory hormone and cholecystokinin reduced, and the expression of intestinal endocrine cells transcription factors encoded by Neurog3 and Neurod1 decreased accordingly (Sakar et al., 2014)
The optimal dose appears to be 4.8 mg for both obesity and MASH indications
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