Advances in Glutathione Research for Disease Research Targeted therapy for GSH metabolism has become a research hotspot, and metabolomics and proteomics technologies have also provided powerful tools for GSH-related research: Targeting GSH metabolism : Inhibiting key molecules such as GCLC, xCT (cysteine uptake carrier) or SLC25A39 (mitochondrial GSH transporter), or using GSH-depleting nanozymes, has shown the potential to enhance ROS-mediated tumor cell death and improve related disease symptoms in preclinical models (such as cell models and animal models), providing new strategies for disease treatment
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In comparison to eukaryotes, studies have shown that most of the residues that are highly conserved in theta and other bacterial class GSTs are not retained in those of the alpha, mu, and pi classes of eukaryotic GSTs
