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Another RCT in newly diagnosed PD patients found that DFP accelerated disease progression and necessitated earlier dopaminergic therapy (Devos et al., 2022)
Furthermore, KIAMO provides intuitive visualization tools, such as scRNA-seq t -distributed stochastic neighbor embedding ( t -SNE) highlighted per gene, heatmaps showing cell type specificity of gene expression and box plots for proteomics data, including statistical tests, which help identify differences in protein levels between young and aged samples
In the liver, accumulation of large quantities of reactive drug metabolites can lead to hepatocellular injury, formation of protein adducts that can act as haptens and stimulate production of auto-antibodies or promote cellular transformation
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