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Subsequent rises in IGF-1 concentrations were noted, persisting for one to two weeks, with prolonged activity observed in repeated exposures

For most people, it lasts a few days to a week and then at least partially subsides as your body adjusts to the medication

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81,82 Mechanistic Basis of Muscle Mass Reduction The extent of skeletal muscle reduction is influenced by factors such as age, baseline cardiometabolic disease, habitual physical activity, nutritional adequacy, and the velocity of weight loss