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Additionally, it plays a role in the hepatic biotransformation and detoxification process

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Back Syn, NL, Cummings, DE, Wang, LZ, et al (2021) 'Association of metabolic-bariatric surgery with long-term survival in adults with and without diabetes: a one-stage meta-analysis of matched cohort and prospective controlled studies with 174 772 participants', The Lancet , 397, 1830-41

Mitochondria cannot manufacture glutathione de novo , so glutathione is synthesized in the cytosol and a small fraction of the total cellular pool is then imported into the mitochondrial matrix by carrier-mediated transport (22