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PMID: 35714602 iScience 2025 Apr 3;28(5):112344
2.6% placebo) - Once-daily oral amycretin: 7.6% placebo-adjusted weight loss at 36 weeks - Significant HbA1c reductions with both formulations This is important because it shows both delivery routes working in the same population
This phenomenon occurs through indirect mechanisms related to weight reduction and metabolic improvements rather than pharmacological stimulation
Were no longer limited to restrictive diets that leave you hungry and exhausted, or extreme measures that feel unsustainable
emphasize the evidence for direct fat loss is limited and dramatic transformations are anecdotal
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