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After the approved drug is on the market, whether generic or branded, API manufacturers must test each batch of the product according to the identified specifications using validated tests and, with each batch, issue a certificate of analysis (COA) that contains specific test results about the substance

Neurogastroenterol Motil 2010;22:12981302

The regulatory pathway for these investigational compounds will likely include specific requirements for post-marketing surveillance and long-term safety monitoring

Proper handling ensures consistent research outcomes

This includes in addition to the skin lesions, the concomitant lesions counteraction, that is, burn stress gastric lesions in severely burned mice (Mikus et al., 2001)