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However, a high-fat diet and subsequent development of NASH can downregulate hepatic GLP-1R expression, thereby inducing therapeutic resistance to this medication in certain patients (Svegliati-Baroni et al., 2011

For patients with cardiovascular disease but not chronic kidney disease, GLP-1 receptor agonists reduce overall mortality, with an NNT of 59 (95% CI, 40 to 112) over five years

What reconstitution and storage steps preserve peptide integrity in the lab

First, side-chain carboxyl groups and hydroxyl groups must be protected as amides or esters