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In addition, cytochrome-c, which can mediate cell apoptosis (reviewed in 89 ), is significantly upregulated in aposymbiotic samples (Figure S3)

The product may be degraded before it ever reaches the nasal epithelium

It increases collagen, elastin, and glycosaminoglycans and supports dermal fibroblasts (skin cells in the dermis)

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When miR-146a levels rise, two key TLR signaling proteins, IRAK1 and TRAF6, may decrease, and thus they may not transmit inflammatory signals inside the cell, including pathways linked to NF-B activation, which would otherwise play a major role in inflammatory signaling