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LTA 4 synthesised in neutrophils is released to neighbouring acceptor cells such as erythrocytes or platelets that lack 5-LOX but possess the enzyme LTA 4 hydrolase and are then able to produce leukotriene LTB 4 , while LTA 4 generated and released from neutrophils is acted upon in acceptor cells such those in the vascular wall by a second LTC 4 synthase (microsomal glutathione S transferase 2 or MGST2) to create LTC 4
Nausea is dose-dependent and most pronounced during the dose-escalation phase, typically diminishing as the body adapts to treatment
(2025a)
Alvarez, E
Role of fatty acid transport protein 4 in oleic acid-induced glucagon-like peptide-1 secretion from murine intestinal L cells
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