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Pharmacokinetic and dose-finding studies on efpeglenatide in patients with type 2 diabetes
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[29] examined treatment resistance in IIH (defined by authors as composite of indicators including requirement for escalation of medical therapy, progression to surgical intervention, need for CSF diversion procedures, or optic nerve decompression or sheath fenestration)) and noted a trend toward fewer refractory cases with tirzepatide (20.5% risk reduction, RR 0.795, p = 0.019 at 24 months)
Additionally, lipoic acid increased mitochondrial biogenesis through triggering AMP-activated protein kinase (AMPK)-induced transcription factor PGC-1 activation in skeletal muscle of aged mice (48)
Sun Y, Campisi J, Higano C, Beer TM, Porter P, Coleman I et al
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