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Its anti-inflammatory effect includes decreasing levels of inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-), making it a potential anti-inflammatory agent

However, this increase appears to be due to the rapid and robust glucose-lowering in people with marked hyperglycemia and preexisting retinopathy phenomenon previously observed in studies of insulin

Results Study design and anthropometry We analyzed data from the ongoing multicenter LI study PLIS that recruited individuals with prediabetes in study centers throughout Germany within the framework of the German Center for Diabetes Research (DZD e.V.), where participants received the intervention for 12 months and were followed up for up to 9 years with metabolic phenotyping including oral glucose tolerance tests (OGTTs) for glucose metabolism and whole-body magnetic resonance imaging (MRI) for assessment of body fat distribution before and after the intervention and during follow-up (see Methods for details)

While these drugs were originally developed for type 2 diabetes and weight management , their effects on hormonal balance, weight loss, and ovulation are now being linked to fertility improvements