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The TNG-CNPs (nitroglycerin-loaded chitosan nanoparticles) system releases NO slowly, activating the soluble guanylate cyclase (sGC)cGMP signaling pathway, thereby inhibiting NADPH oxidase activity, reducing O production, and upregulating eNOS expression, improving renal tissue perfusion status
ASCO 12:309, 1993
It may take some time for the medicine to be effective
McCreight, L
10.1093/cvr/cvaa094 19
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