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Retatrutide * Triple agonist: GLP-1 + GIP + Glucagon * Pushing biology harder * ~2528% weight loss in trials * Once weekly injection This is efficacy chasing bariatric territory Orforglipron * Oral, non-peptide GLP-1 * No injection, no cold chain drama * Strong A1C + weight data vs oral sema This is scalability at massive level In one line: Retatrutide stretches the ceiling

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Data from participants without events of interest were censored at the end of their trial observation period