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The effects of GLP-1RAs on colorectal and other cancer risk Clinical studies have demonstrated that the use of GLP-1RAs can reduce the risk of colorectal cancer, and the protective effect appears to be positively correlated with the duration of therapy

Gallbladder/biliary issues (stones, inflammation) have been linked in some research

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Retatrutide Retatrutide is an investigational peptide that activates the GLP-1, GIP, and glucagon receptors