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The main criterion for establishing the AI for choline was the prevention of liver damage
It is a fragment derived from a naturally occurring protective protein identified in gastric juice and is widely studied in laboratory models of cellular signalling and tissue repair pathways
A subsequent study identified the compound N-(4-(2-(4-(trifluoromethyl)phenyl)thiazol-4-yl)phenyl)acetamide as a notable SARM1 inhibitor, which demonstrated significant efficacy in a mouse model of CIPN (Fig
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doi: 10.2337/db08-0349 26
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