Dentro del programa STEP (Semaglutide Treatment Effect in People with Obesity), en STEP-2 se evalu el efecto de la dosis de 2,40mg de semaglutida en personas con obesidad y DM2 durante 68 semanas
Interestingly, aged mice exhibited a re-emergence of several youthful phenotypic traits following treatmentincluding increased physical activity, improved cognitive performance, and enhanced fur density
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The final step in establishing preclinical proof-of-hypothesis was made when the results of these acute studies were recapitulated with chronic dosing, showing that the beneficial pancreatic islet and glucose-lowering effects of DPP-4 inhibition persisted over several months of treatment (30, 31)