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GHK-Cu studies examine the peptide's effects on both collagen synthesis and breakdown processes in fibroblast cultures
Recent human topical evidence A 2023 IRB-approved 21-woman topical trial of NEEL gel (a stabilized GHK-Cu topical) reported an average 28% increase in skin collagen density at 3 months, with a top quartile reporting 51%
In preclinical studies, BPC-157 has been observed to accelerate connective tissue healing , upregulate VEGF expression , and modulate the nitric oxide (NO) pathway to support vascular integrity
In order to maintain oxidative homeostasis, the cells need to increase their antioxidant capacity
