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03 Stability, Storage & Multi-Dose Handling The 28-Day Rule for Punctured Multi-Dose Vials Unopened vials should be stored at controlled room temperature, 20C to 25C (68F to 77F)

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doi: 10.3389/fmed.2025.1670225 Received 21 July 2025 Revised 05 December 2025 Accepted 16 December 2025 Published 12 January 2026 Volume 12 - 2025 Edited by Redhwan Ahmed Al-Naggar, National University of Malaysia, Malaysia Reviewed by Eric Chu, EC Healthcare, Hong Kong SAR, China Mateus Henrique Dias Guimares, Christian Business School (CBS), United States Updates Copyright 2026 Guan, Shi and Zhao

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