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Dimerization with stimulation of MC3R leads to a twofold amplification of MC3R-induced cAMP accumulation (top), while the GHSR1a protomer shows a ligand-dependent as well as ligand-independent 40% reduction in Ca 2+ accumulation when dimerized with MC3R (bottom)
The compound has been studied in models of traumatic brain injury, peripheral nerve damage, neurotoxicity, and mood disorders producing results that have surprised many researchers given the peptides gastrointestinal origins
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doi:10.1006/bbrc.2000.2267
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