Nat Rev Drug Discov 15:379380 Sun D, Gao W, Hu H, Zhou S (2022) Why 90% of clinical drug development fails and how to improve it
On that same note, it was recently demonstrated that a generalized reversal of functionally relevant transcriptomic changes at the genome-wide level in multiple glial and vascular cell types of the brain is pharmacologically achievable with GLP-1RA treatment [98]
However, neurodegenerative disease mechanisms differ substantially between animal models and human diseases, and premature clinical use based solely on animal data could expose patients to unknown risks without established benefits
Neuron, 110 (12), 18991923
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