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In mice, GDF-15 increases satiety and reduces food intake through actions in the central nervous system [99]

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In addition, animal models with disrupted heat shock-related genes or pathways, including those associated with HSPA5 and HSP90, further suggest that aberrant HSP expression or dysfunction may contribute to meiotic arrest, spermatogenic failure, and even loss of fertility

This approach helps maintain effectiveness and allows assessment of whether benefits persist when off the peptide

Additionally, DSIP has been linked to neuroprotective properties , potentially aiding in the protection of brain cells against oxidative stress and other damaging processes