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While they found better skin outcomes in participants who used hydroquinone cream (a common melasma intervention), they also concluded that topical silymarin was also effective and produced fewer side effects.28 Wrinkles A lack of skin moisture is one of the factors behind fine lines and wrinkles.29 According to a 2012 study published in the African Journal of Biotechnology , milk thistle extract, emulsified into a topical cream, may help combat wrinkle formation by boosting moisture retention and preventing transepidermal water loss.30 An important caveat to consider is that all of our top recommended milk thistles are oral supplements, and research on oral milk thistle for the above purposes is somewhat lacking

Synthetic melanocortin stimulation works through systemic mechanism

Maternal multiple micronutrient supplementation in rural Pakistan increased some milk micronutrient concentrations, but not infant growth, at three-months postpartum: a randomized controlled trial substudy

Within the first 2 months of treatment, noticeable changes will be seen and felt in most patients