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Idebenone: Clinical Potential Beyond Neurological Diseases
Long-term safety endpoints had the primarily purpose of excluding the presence of infections due the possible non-sterility of the cell product (a risk minimized by the extensive in vitro examinations), tumor formation (risk minimized by the in vivo evidence obtained by infusion of supra maximal doses of cells in immunosuppressed mice) as well as changes in neurological status that would not be expected based on the disease course
Approximately 510% of APAP undergoes hepatic metabolism by cytochrome CYP 2E1, as a consequence, a highly reactive and harmful metabolite known as N -acetyl-para-benzoquinone imine (NAPQI), Fig
While no peptide can halt this entirely, early evidence suggests Epitalon may help preserve key cognitive functions by intervening at multiple points in the neurodegenerative cascade
doi: 10.1007/s12602-025-10636-w 196 Hernndez-GonzlezJCMartnez-TapiaALazcano-HernndezGGarca-PrezBECastrejn-JimnezNS
