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Notably, however, whereas weight loss induced by GLP-1GIPLani and GLP-1RGIPR co-agonism was much stronger in GIPR transgenic mice relative to wild-type controls, they both equally induced weight loss in GIPR transgenic mice (Extended Data Fig
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The hormone acts simultaneously on the brain (satiety), pancreas (insulin release, glucagon suppression), and stomach (slowed emptying)
Strategic site selection during dose escalation Dose escalation is when most side effects occur
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