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Personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, or severe gastrointestinal conditions like gastroparesis may rule out tirzepatide and similar GLP-1 based therapies

Its deficiency can lead to cellular stress and dysfunction, underscoring its vital role in maintaining cellular health

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Collecting urine over a 24-hour period can give deeper insights into GFR and creatinine clearance, but this method could be burdensome and may yield inaccurate results if not collected properly

Tirzepatide is the active ingredient in Zepbound, a GLP-1 receptor agonist